LSF-IDM: Automotive Intrusion Detection Model with Lightweight Attribution and Semantic Fusion

Autonomous vehicles (AVs) are more vulnerable to network attacks due to the high connectivity and diverse communication modes between vehicles and external networks. Deep learning-based Intrusion detection, an effective method for detecting network attacks, can provide functional safety as well as a real-time communication guarantee for vehicles, thereby being widely used for AVs. Existing works well for cyber-attacks such as simple-mode but become a higher false alarm with a resource-limited environment required when the attack is concealed within a contextual feature. In this paper, we present a novel automotive intrusion detection model with lightweight attribution and semantic fusion, named LSF-IDM. Our motivation is based on the observation that, when injected the malicious packets to the in-vehicle networks (IVNs), the packet log presents a strict order of context feature because of the periodicity and broadcast nature of the CAN bus. Therefore, this model first captures the context as the semantic feature of messages by the BERT language framework. Thereafter, the lightweight model (e.g., BiLSTM) learns the fused feature from an input packet's classification and its output distribution in BERT based on knowledge distillation. Experiment results demonstrate the effectiveness of our methods in defending against several representative attacks from IVNs. We also perform the difference analysis of the proposed method with lightweight models and Bert to attain a deeper understanding of how the model balance detection performance and model complexity.Comment: 18 pages, 8 figure

Tracing blastomere fate choices of early embryos in single cell culture

Blastomeres of early vertebrate embryos undergo numerous fate choices for division, motility, pluripotency maintenance and restriction culminating in various cell lineages. Tracing blastomere fate choices at the single cell level in vitro has not been possible because of the inability to isolate and cultivate early blastomeres as single cells. Here we report the establishment of single cell culture system in the fish medaka, enabling the isolation and cultivation of individual blastomeres from 16- to 64-cell embryos for fate tracing at the single cell level in vitro. Interestingly, these blastomeres immediately upon isolation exhibit motility, lose synchronous divisions and even stop dividing in ≥50% cases, suggesting that the widely accepted nucleocytoplasmic ratio controlling synchronous divisions in entire embryos does not operate on individual blastomeres. We even observed abortive division, endomitosis and cell fusion. Strikingly, ~5% of blastomeres in single cell culture generated extraembryonic yolk syncytial cells, embryonic stem cells and neural crest-derived pigment cells with timings mimicking their appearance in embryos. We revealed the maternal inheritance of key lineage regulators and their differential expression in cleavage embryos. Therefore, medaka blastomeres possess the accessibility for single cell culture, previously unidentified heterogeneity in motility, division, gene expression and intrinsic ability to generate major extraembryonic and embryonic lineages without positioning cues. Our data demonstrate the fidelity and potential of the single cell culture system for tracking blastomere fate decisions under defined conditions in vitro

Recent novel tumor gatekeepers and potential therapeutic approaches (2017)

Tumor remains a challenging task for oncology community. Drug resistance due to chemotherapy remain principal impediments  toward potential therapeutic strategies. Development of novel anti-cancer drugs or new targeted strategies to conquer drug  resistance is a key goal of cancer research. In this respect, novel tumor gatekeepers and innovative targeted strategies can be  helpful in overcoming drug resistance as well as improve currently used targeted therapies. In this review, efforts have been made to present some of the latest knowledge about novel tumor gatekeepers and new therapeutic strategies to improve the efficacy of  chemotherapy and give new hope to cancer patients to fight against cancer.Keywords: Cancer, Potent inhibitors, Gatekeepers, Therapeutic approaches, Oncogenic pathway

Differential Conservation and Divergence of Fertility Genes boule and dazl in the Rainbow Trout

10.1371/journal.pone.0015910PLoS ONE61

Flying to Quality: Cultural Influences on Online Reviews

Customers increasingly consult opinions expressed online before making their final decisions. However, inherent factors such as culture may moderate the criteria and the weights individuals use to form their expectations and evaluations. Therefore, not all opinions expressed online match customers’ personal preferences, neither can firms use this information to deduce general conclusions. Our study explores this issue in the context of airline services using Hofstede’s framework as a theoretical anchor. We gauge the effect of each dimension as well as that of cultural distance between the passenger and the airline on the overall satisfaction with the flight as well as specific service factors. Using topic modeling, we also capture the effect of culture on review text and identify factors that are not captured by conventional rating scales. Our results provide significant insights for airline managers about service factors that affect more passengers from specific cultures leading to higher satisfaction/dissatisfaction

Stress analysis of the structural interface between the spar and the torus in the combined wind and wave energy concept STC

The Spar Torus Combination (STC) is a typical concept which consists of a spar-type floating wind turbine (FWT) and a torus-shaped wave energy converter (WEC), which utilizes the wind energy and wave energy simultaneously. The STC concept reduces the capital costs and improves the utilization of the ocean energy. The study focuses on the interface between the spar and the torus. According to the previous numerical and experimental studies, the interface is expected to undergo extremely large wave loads . The "roller-guide" interface is designed and established in ABAQUS. Nonlinear local structural modelling of the interface is carried out in this thesis. The WEC is established to be connected to the spar cylinder with designed rollers and hydraulic supports. Rubber rollers and spring connectors are used to absorb the wave energy so that the contact stress in the interface is not significant. Different scenarios are defined to investigate the performance of the interface structure. Quasi-static analyses are performed, and the elementary dynamic effect is investigated. The results have been discussed in this thesis